PandemieGrippaleV1, Main, Exploration, bibRecord, 000A35

A Lentiviral Vector Expressing Japanese Encephalitis Virus-like Particles Elicits Broad Neutralizing Antibody Response in Pigs

Identifieur interne : 000A35 ( Main/Exploration ); précédent : 000A34; suivant : 000A36

A Lentiviral Vector Expressing Japanese Encephalitis Virus-like Particles Elicits Broad Neutralizing Antibody Response in Pigs

Auteurs : Mélissanne De Wispelaere [France] ; Meret Ricklin [Suisse] ; Philippe Souque [France] ; Marie-Pascale Frenkiel [France] ; Sylvie Paulous [France] ; Obdulio Garcìa-Nicolàs [Suisse] ; Artur Summerfield [Suisse] ; Pierre Charneau [France] ; Philippe Desprès [France]

Source :

PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2015-10-05.

RBID : Hal:pasteur-01212231

Descripteurs français

Wicri :
- topic : Porcin, Vaccin.

English descriptors

mix :
- Antibodies, Enzyme-linked immunosorbent assay, Inoculation, Japanese Encephalitis Virus, Lentiviral vector, Mouse model, Recombinant Proteins, Swine, Vaccine.

Abstract

Japanese encephalitis virus is the etiologic agent of the most medically important viral encephalitis in South Asia with thousands of deaths per year. The virus is maintained in an enzootic cycle between Culex mosquitoes and amplifying vertebrate hosts, such as wild boars and pigs. Vaccination of domestic pigs has been suggested as a strategy to reduce viral disease transmission to humans, in line with the now-called “One Health” concept. Lentiviral gene transfer vectors represent a novel vaccination platform with an unprecedented ability to induce robust humoral immunity in various animal species. In our study, we demonstrated that immunization of pigs with a recombinant lentiviral vector expressing virus-like particles of Japanese encephalitis virus is particularly efficient at eliciting specific humoral immunity. The titers of neutralizing antibodies elicited by the lentiviral vector are sufficient to confer protection in domestic pigs against the different genotypes of Japanese encephalitis virus observed in Asia.

Url:

https://hal-pasteur.archives-ouvertes.fr/pasteur-01212231

DOI: 10.1371/journal.pntd.0004081

Affiliations:

France, Suisse

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000013
to stream Hal, to step Curation: 000013
to stream Hal, to step Checkpoint: 000369
to stream Main, to step Merge: 000A39
to stream Main, to step Curation: 000A35

Le document en format XML

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          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Despres, Philippe" sort="Despres, Philippe" uniqKey="Despres P" first="Philippe" last="Desprès">Philippe Desprès</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-7876" status="OLD">          <orgName>Interactions Moléculaires Flavivirus-Hôtes</orgName>
          <desc>            <address>              <addrLine>25-28 rue du Docteur Roux, F-75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300027" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID">          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <date type="start">1887-06-04</date>
          <desc>            <address>              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1371/journal.pntd.0004081</idno>
<series><title level="j">PLoS Neglected Tropical Diseases</title>
<idno type="ISSN">1935-2727</idno>
<imprint><date type="datePub">2015-10-05</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Antibodies</term>
<term>Enzyme-linked immunosorbent assay</term>
<term>Inoculation</term>
<term>Japanese Encephalitis Virus</term>
<term>Lentiviral vector</term>
<term>Mouse model</term>
<term>Recombinant Proteins</term>
<term>Swine</term>
<term>Vaccine</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Porcin</term>
<term>Vaccin</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>Japanese encephalitis virus is the etiologic agent of the most medically important viral encephalitis in South Asia with thousands of deaths per year. The virus is maintained in an enzootic cycle between Culex mosquitoes and amplifying vertebrate hosts, such as wild boars and pigs. Vaccination of domestic pigs has been suggested as a strategy to reduce viral disease transmission to humans, in line with the now-called “One Health” concept. Lentiviral gene transfer vectors represent a novel vaccination platform with an unprecedented ability to induce robust humoral immunity in various animal species. In our study, we demonstrated that immunization of pigs with a recombinant lentiviral vector expressing virus-like particles of Japanese encephalitis virus is particularly efficient at eliciting specific humoral immunity. The titers of neutralizing antibodies elicited by the lentiviral vector are sufficient to confer protection in domestic pigs against the different genotypes of Japanese encephalitis virus observed in Asia.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Suisse</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="De Wispelaere, Melissanne" sort="De Wispelaere, Melissanne" uniqKey="De Wispelaere M" first="Mélissanne" last="De Wispelaere">Mélissanne De Wispelaere</name>
</noRegion>
<name sortKey="Charneau, Pierre" sort="Charneau, Pierre" uniqKey="Charneau P" first="Pierre" last="Charneau">Pierre Charneau</name>
<name sortKey="Despres, Philippe" sort="Despres, Philippe" uniqKey="Despres P" first="Philippe" last="Desprès">Philippe Desprès</name>
<name sortKey="Frenkiel, Marie Pascale" sort="Frenkiel, Marie Pascale" uniqKey="Frenkiel M" first="Marie-Pascale" last="Frenkiel">Marie-Pascale Frenkiel</name>
<name sortKey="Paulous, Sylvie" sort="Paulous, Sylvie" uniqKey="Paulous S" first="Sylvie" last="Paulous">Sylvie Paulous</name>
<name sortKey="Souque, Philippe" sort="Souque, Philippe" uniqKey="Souque P" first="Philippe" last="Souque">Philippe Souque</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Ricklin, Meret" sort="Ricklin, Meret" uniqKey="Ricklin M" first="Meret" last="Ricklin">Meret Ricklin</name>
</noRegion>
<name sortKey="Garcia Nicolas, Obdulio" sort="Garcia Nicolas, Obdulio" uniqKey="Garcia Nicolas O" first="Obdulio" last="Garcìa-Nicolàs">Obdulio Garcìa-Nicolàs</name>
<name sortKey="Summerfield, Artur" sort="Summerfield, Artur" uniqKey="Summerfield A" first="Artur" last="Summerfield">Artur Summerfield</name>
</country>
</tree>
</affiliations>
</record>

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A Lentiviral Vector Expressing Japanese Encephalitis Virus-like Particles Elicits Broad Neutralizing Antibody Response in Pigs

A Lentiviral Vector Expressing Japanese Encephalitis Virus-like Particles Elicits Broad Neutralizing Antibody Response in Pigs

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